[Atherosclerosis, oxidative stress and physical activity. Review]

Area of Science:

• Cardiovascular Science
• Oxidative Stress Research
• Public Health

Context:

• Atherosclerosis is a leading cause of death globally.
• Oxidative stress is implicated in atherosclerosis pathophysiology.
• Physical activity is a key public health intervention for cardiovascular disease prevention.

Purpose:

• To explore the relationship between atherosclerosis, oxidative stress, and physical activity.
• To address the paradox of physical activity reducing cardiovascular risk while increasing oxidative stress.

Summary:

• Physical activity is known to reduce atherosclerosis and cardiovascular events.
• However, physical activity also increases reactive oxygen species production, a component of oxidative stress.
• This review presents a hypothesis supported by evidence to resolve this apparent contradiction.

Impact:

• Provides a framework for understanding the complex interplay of exercise, oxidative stress, and vascular health.
• Informs public health strategies for promoting cardiovascular wellness.
• Highlights the net beneficial effects of physical activity on atherosclerosis despite transient oxidative stress.