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Updated: Jun 29, 2026
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Systemic lupus erythematosus and pregnancy].
Véronique Le Guern1, Emmanuelle Pannier, François Goffinet
1Service de Médecine Interne, Hôpital Cochin, Université Paris Descartes, Paris, France. veronique.le-guern@cch.aphp.fr
Presse Medicale (Paris, France : 1983)
|October 14, 2008
Summary
Systemic lupus erythematosus (SLE) pregnancy outcomes have improved with better management. SLE patients can conceive if their disease is inactive for 6 months, requiring multidisciplinary care to mitigate risks.
Area of Science:
- Rheumatology
- Obstetrics
- Immunology
Context:
- Systemic lupus erythematosus (SLE) primarily impacts women of reproductive age.
- Advances in SLE therapeutics and obstetric care have significantly improved pregnancy prognosis.
Purpose:
- To outline the current understanding and management of pregnancy in women with SLE.
- To highlight the necessity of a multidisciplinary approach for managing SLE pregnancies.
Summary:
- Pregnancy is feasible for SLE patients with inactive disease for at least six months.
- Key risks include lupus flares and obstetrical complications like fetal loss, preterm birth, intrauterine growth retardation, and preeclampsia.
- Safe medications include corticosteroids, hydroxychloroquine, and azathioprine, which should be continued if indicated.
Impact:
- Facilitates informed decision-making for SLE patients considering pregnancy.
- Guides healthcare providers in establishing optimal multidisciplinary care protocols.
- Contributes to improved maternal and fetal outcomes in SLE pregnancies.
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