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Biophysical studies with parallel stranded oligoduplex
Pradip Bhattacharya1, Ramesh K Bamezai
1Laboratory 332, School of Life Sciences, Jawaharlal Nehru University, New Delhi-110067, India. pbhattacharya@mail.jnu.ac.in
Abstract:
The thermal denaturation profiles of parallel stranded oligoduplexes during UV-spectroscopy and fluorescence spectroscopy, for the first time, were shown to follow the similar patterns as were described for antiparallel stranded oligoduplexes. The B-form structure of these center-bubble-forming oligoduplexes was determined with circular dichroism. Thermodynamic properties were also discussed.
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