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Program oversight enhancements (POE): the big PAM
1Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. plantea@wyeth.com
ILAR Journal
|October 14, 2008
Summary
Researchers can enhance animal research compliance using program oversight enhancements (POE) instead of solely relying on postapproval monitoring (PAM). POE offers flexible, institution-specific methods to ensure adherence to animal welfare regulations and IACUC protocols.
Area of Science:
- Veterinary science
- Research ethics
- Animal welfare science
Background:
- Federal regulations mandate animal welfare compliance in research.
- Oversight and assessment methods are institution-specific, often managed by Institutional Animal Care and Use Committees (IACUCs).
- Postapproval monitoring (PAM) has gained popularity but is not federally mandated.
Purpose of the Study:
- To describe alternative compliance mechanisms to PAM.
- To introduce Program Oversight Enhancements (POE) as a viable alternative for ensuring compliance with IACUC-approved animal research.
- To provide adaptable strategies for institutions to improve animal research oversight.
Main Methods:
- Describing various POE strategies.
- Presenting POE as a flexible, customizable approach.
- Highlighting the potential for institutions to select and implement chosen enhancements.
Main Results:
- POE offers a range of options for institutions to tailor compliance monitoring.
- Implementing even a few POE strategies can improve adherence to approved protocols.
- POE can reduce the reliance on intensive, formal PAM processes.
Conclusions:
- Program Oversight Enhancements (POE) provide a valuable alternative to postapproval monitoring (PAM) for ensuring animal research compliance.
- Institutions can adopt flexible POE strategies to meet their specific needs and improve animal welfare oversight.
- POE can enhance compliance and potentially reduce the burden of extensive monitoring.
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