Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
Cellular Differentiation00:57

Cellular Differentiation

How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A machine-learning-derived online prediction model for risk during the activity period in SLE patients: a retrospective historical cross-sectional study.

BMC rheumatology·2026
Same author

Correction: Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue.

eLife·2026
Same author

Thioredoxin system dysregulation and calpain activation drive myocardial disulfidptosis via pathological disulfide bonds remodeling.

Cell death discovery·2026
Same author

Multiscale impacts of harmful algal blooms and toxins on aquatic ecosystem structure and function: a systematic review.

Environmental science. Processes & impacts·2026
Same author

Response to Zhao et al, "Comment on 'Nevus-associated acral melanoma has lower risk of recurrence and mortality than de novo acral melanoma'".

Journal of the American Academy of Dermatology·2026
Same author

Identification of shared diagnostic biomarkers and molecular pathways between chronic kidney disease and renal cell carcinoma using transcriptomics and machine learning.

Translational cancer research·2026

Related Experiment Video

Updated: Jun 29, 2026

Differentiation of Mouse Breast Epithelial HC11 and EpH4 Cells
09:32

Differentiation of Mouse Breast Epithelial HC11 and EpH4 Cells

Published on: February 27, 2020

Ghrelin and cell differentiation.

Geyang Xu1, Yin Li, Wenjiao An

  • 1Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China.

Acta Biochimica Et Biophysica Sinica
|October 14, 2008
PubMed
Summary
This summary is machine-generated.

Ghrelin, a gastric hormone, influences cell differentiation and tissue development. This review focuses on its role in mesenchymal stem cell lineage determination.

More Related Videos

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

Related Experiment Videos

Last Updated: Jun 29, 2026

Differentiation of Mouse Breast Epithelial HC11 and EpH4 Cells
09:32

Differentiation of Mouse Breast Epithelial HC11 and EpH4 Cells

Published on: February 27, 2020

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

Area of Science:

  • Endocrinology
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Ghrelin is an endogenous peptide hormone and the primary endogenous ligand for the growth hormone secretagogue receptor (GHSR).
  • Ghrelin exhibits diverse physiological functions beyond its established role in regulating growth hormone secretion and energy homeostasis.
  • Emerging evidence suggests ghrelin plays a significant role in cellular processes like differentiation and development.

Purpose of the Study:

  • To review the current understanding of ghrelin's effects on cell differentiation.
  • To summarize ghrelin's impact on tissue development.
  • To specifically highlight the influence of ghrelin on the lineage determination of mesenchymal stem cells (MSCs).

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of research investigating ghrelin signaling pathways.
  • Synthesis of data on ghrelin's impact on stem cell behavior.

Main Results:

  • Ghrelin signaling impacts the differentiation of various cell types.
  • Evidence suggests ghrelin influences developmental processes at the tissue level.
  • Ghrelin plays a role in directing the fate of mesenchymal stem cells towards specific lineages.

Conclusions:

  • Ghrelin is a key regulator of cell differentiation and tissue development.
  • Ghrelin's influence on mesenchymal stem cell lineage determination is a critical area of study.
  • Further research into ghrelin's developmental roles could reveal therapeutic targets.