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Published on: December 6, 2016

Secretion of antidiuretic hormone in children with obstructive sleep apnea-hypopnea syndrome

Zhiyong Yue1, Mingming Wang, Wei Xu

  • 1Department of Otorhinolaryngology, Provincial Hospital Affiliated to Shandong University, Jinan, China.

Acta Oto-Laryngologica
|October 14, 2008
PubMed

Insights

Pediatric obstructive sleep apnea-hypopnea syndrome (OSAHS) can affect antidiuretic hormone (ADH) secretion, leading to increased nighttime urination. Treatment improved ADH levels and reduced urination in children with OSAHS.

Area of Science:

  • Pediatric Sleep Medicine
  • Endocrinology
  • Respiratory Medicine

Background:

  • Obstructive sleep apnea-hypopnea syndrome (OSAHS) in children is often associated with adenotonsillar hypertrophy.
  • Hypoxemia during sleep in pediatric OSAHS may impact hormonal regulation.
  • Nocturnal polyuria and nocturia are potential symptoms linked to sleep-disordered breathing.

Purpose of the Study:

  • To investigate the effect of OSAHS on antidiuretic hormone (ADH) secretion in children.
  • To assess changes in ADH levels and nocturnal urine volume following adenotonsillectomy in pediatric patients with OSAHS.

Main Methods:

  • A study involving 48 children, with 28 diagnosed with OSAHS and 20 as healthy controls.
  • Polysomnography was used to monitor respiratory indexes, and 12-hour nocturnal urine volume was recorded.
  • Serum ADH levels were measured using radioimmunoassay before and after adenotonsillectomy.

Main Results:

  • Adenotonsillectomy significantly reduced the apnea-hypopnea index (AHI) and improved lowest arterial oxygen saturation (LSaO2).
  • Post-surgery, nocturnal urine volume decreased, and serum ADH levels increased significantly in children with OSAHS.
  • Following treatment, differences in urine volume and ADH levels between formerly OSAHS patients and healthy controls were not statistically significant.

Conclusions:

  • Obstructive sleep apnea-hypopnea syndrome in children with hypoxemia may alter nocturnal ADH secretion.
  • These alterations in ADH are potentially linked to the development of polyuria and nocturia in affected children.
  • Adenotonsillectomy appears to normalize ADH secretion and reduce nocturnal enuresis in pediatric OSAHS patients.
Abstract

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