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Published on: September 12, 2014
Amniotic membrane transplantation in severe ocular surface disorders.
1Department of Ophthalmology, RWTH Aachen University, Aachen - Germany. marion.kaup@post.rwth-aachen.de
European Journal of Ophthalmology
|October 14, 2008
Summary
Amniotic membrane transplantation for severe corneal disorders can lead to complications like perforation and descemetocele in 25% of patients. Careful consideration of risks and follow-up is crucial.
Area of Science:
- Ophthalmology
- Regenerative Medicine
Background:
- Amniotic membrane transplantation (AMT) is a therapeutic option for severe corneal surface disorders unresponsive to conventional treatments.
- AMT utilizes the regenerative and anti-inflammatory properties of the amniotic membrane.
Observation:
- This study reports complications in patients undergoing AMT for conditions such as severe chemical burns, corneal ulceration, and persistent epithelial defects.
- A case series of 28 patients demonstrated significant adverse events post-transplantation.
Findings:
- Within six weeks of AMT, 25% of patients experienced serious complications, including spontaneous corneal perforation (4 patients) and descemetocele formation (3 patients).
- These complications may stem from the underlying disease severity or the biological effects of the amniotic membrane on corneal tissue.
Implications:
- The potential for corneal thinning and perforation necessitates careful patient selection and vigilant monitoring following AMT.
- Risk-benefit assessment is vital when considering AMT for complex corneal surface diseases.
