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[Advances in histone methyltransferases and histone demethylases]

Xi Wang1, Wei-Guo Zhu

  • 1Department of Biochemistry and Molecular Biology, Peking University,Health Science Center, Beijing, 100191 P. R. China.

AI Zheng = Aizheng = Chinese Journal of Cancer
|October 15, 2008
PubMed

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Acetylation
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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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