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Targeting Inflammation and Immune Regulation in Chronic Inflammation Associated Cancers.
Lawan Rabiu1, Mengzhu Chinn1, Feng Chen1
1Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen, China.
Cancer Science
|March 10, 2026
Summary
Chronic inflammation drives cancer, particularly colitis-associated cancer (CAC) and liver cancer (MAFLD-HCC). Impaired immune regulation, like reduced TIPE2 activity, promotes tumor growth, offering targets for prevention and treatment.
Area of Science:
- Oncology
- Immunology
- Inflammation Research
Background:
- Chronic inflammation is a key driver of cancer development, promoting genomic instability and malignant transformation.
- Inflammation-associated malignancies like colitis-associated cancer (CAC) and metabolic dysfunction-associated fatty liver disease-related hepatocellular carcinoma (MAFLD-HCC) arise from prolonged preneoplastic stages.
- These cancers share common inflammatory and oncogenic pathways, including IL-6/STAT3 and NF-κB signaling.
Purpose of the Study:
- To synthesize shared inflammatory, immunologic, and microenvironmental mechanisms in CAC and MAFLD-HCC.
- To emphasize how impaired immune regulation contributes to cancer development.
- To highlight therapeutic and preventive strategies targeting inflammation-driven pathways.
Main Methods:
- Review of existing literature on inflammation-associated cancers.
- Analysis of shared molecular and cellular mechanisms.
- Identification of immunoregulatory pathways, including TIPE2.
- Synthesis of therapeutic and preventive strategies.
Main Results:
- CAC and MAFLD-HCC share convergent mechanisms involving sustained inflammatory signaling and genetic alterations.
- Failure of endogenous immunoregulatory systems, such as reduced TIPE2 activity, promotes a tumor-promoting microenvironment.
- Impaired immune regulation is critical in transitioning chronic inflammation to cancer.
Conclusions:
- Understanding shared inflammatory pathways is crucial for both cancer prevention and treatment.
- Targeting immune regulation offers dual benefits for preventing cancer in chronic inflammatory diseases and treating established malignancies.
- Modulating inflammation-driven pathways presents a promising therapeutic avenue.
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