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Updated: Jun 29, 2026
12:18
An Instrumented Pull Test to Characterize Postural Responses
Published on: April 6, 2019
Dyskinesia-induced postural instability in Parkinson's disease
Stéphane Armand1, Theodor Landis, Roman Sztajzel
1Kinesiology Laboratory, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Parkinsonism & Related Disorders
|October 15, 2008
Summary
Levodopa-induced dyskinesia (LID) significantly worsens balance in Parkinson's disease (PD) patients. This study found LID increases postural instability, impacting daily unsteadiness and balance control in advanced PD.
Area of Science:
- Neurology
- Movement Disorders
- Biomedical Engineering
Background:
- Parkinson's disease (PD) patients often experience unsteadiness.
- Levodopa-induced dyskinesia (LID) can coexist with PD, but its effect on balance is understudied.
Purpose of the Study:
- To investigate the impact of LID on postural stability in advanced PD patients.
- To quantify the relationship between LID severity and postural control deficits.
Main Methods:
- Utilized static and dynamic posturography with force platforms.
- Measured postural stability parameters (COPnet displacement, ellipse area) in OFF and ON states.
- Assessed LID severity using clinical scales and subjective unsteadiness ratings.
Main Results:
- Significant increase in COPnet displacement (up to 556%) when ON with LID compared to OFF.
- Marked increase in instability correlated with subjective unsteadiness in half of patients.
- Good correlation observed between LID severity scores and postural stability measures.
Conclusions:
- Levodopa-induced dyskinesia (LID) significantly compromises postural stability in advanced Parkinson's disease (PD).
- LID appears to be an independent contributor to balance impairment in PD patients.
- Patients may adopt compensatory weight-shifting strategies to manage LID-related instability.
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