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Updated: Jun 29, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Lysine-enriched cecropin-mellitin antimicrobial peptides with enhanced selectivity
1Department of Microbiology and Molecular Genetics and Center for Biopreparedness and Infectious Disease, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Abstract:
Lysine-enriched analogs of the cecropin-mellitin hybrid peptide, CA(1-7) M(2-9) (designated CM15), designed with optimized amphipathicity, retained antimicrobial activities similar to that of wild-type CM15 and had substantially reduced levels of hemolytic activity and cytotoxicity toward cultured macrophages, resulting in enhanced selectivity. These lysine-enriched analogs provide templates for improved CM15 peptide or peptidomimetic antibiotics.
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