Combined Monocyte Chemoattractant Protein-1 and High-Sensitivity C-Reactive Protein Predict Mortality Rates in the...

Area of Science:

• Biomarkers
• Cardiovascular Disease
• Epidemiology

Background:

• Monocyte chemoattractant protein-1 (MCP-1) and high-sensitivity C-reactive protein (hs-CRP) are key early atherosclerosis biomarkers.
• Their association with mortality in a healthy population requires investigation.

Purpose of the Study:

• To examine the link between serum MCP-1 and hs-CRP levels and mortality.
• To assess prediction of all-cause and cause-specific deaths.

Main Methods:

• Serum MCP-1 and hs-CRP levels were measured in 568 healthy adults.
• Participants were categorized into high/low biomarker groups based on median values.
• Kaplan-Meier curves and Cox regression analyzed mortality over a median 17.9-year follow-up.

Main Results:

• Elevated MCP-1 and hs-CRP were linked to higher all-cause mortality.
• Combined high levels showed adjusted hazard ratios of 1.86 for all-cause, 3.24 for CVD/stroke, and 3.28 for cancer deaths.
• Significant associations were observed for cardiovascular disease (CVD) and cancer mortality.

Conclusions:

• Combined serum MCP-1 and hs-CRP levels can predict mortality.
• These biomarkers offer prognostic value for all-cause, CVD, and cancer deaths in the general population.