Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...

Myocarditis III: Medical Management

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...

Myocarditis I: Introduction

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...

Myocarditis IV: Nursing Management

Myocarditis IV: Nursing Management

Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...

Hypersensitivity Reactions: Cytolytic Reactions

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Health-related quality of life in oropharyngeal cancer survivors - a population-based study.

Otolaryngologia polska = The Polish otolaryngology·2018

Same author

[Quality of life after primary radiation/radiochemotherapy vs. operation therapy in an oropharyngeal cancer].

Laryngo- rhino- otologie·2012

Same author

[A short-term diagnostic and economic impact model of neonatal screening for cystic fibrosis].

Klinische Padiatrie·2011

Same author

Pulmonary Palacos embolism: a case report.

The Thoracic and cardiovascular surgeon·2010

Same author

[Primary nodal follicular lymphoma with secondary cutaneous manifestations. First-line rituximab monotherapy].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2010

Same author

Comparison of photorefractive-index changes in annealed-proton-exchanged channel waveguides in MgO-doped and congruent LiNbO(3).

Optics letters·2009

Same journal

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022

Same journal

[Viral infections of the skin].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022

Same journal

[Viral exanthems in children].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022

Same journal

[Erratum to: Digital health applications and data protection].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022

Same journal

[Virus-induced exanthems in returning travellers].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022

Same journal

[Venous ulcus cruris-Surgical treatment].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2022

See all related articles

Search research articles

Related Experiment Videos

[Simvastatin-induced dermatomyositis].

A Rasch¹, M Schimmer, C A Sander

¹Eduard-Arning-Klinik für Dermatologie und Allergologie, Asklepios Klinik St. Georg , Lohmühlenstrasse 5, 20099, Hamburg. raschastrid@hotmail.com

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|October 15, 2008

Summary

This summary is machine-generated.

Simvastatin, a common cholesterol-lowering drug, may trigger dermatomyositis, a rare autoimmune condition. This case report highlights simvastatin as a potential cause of this serious side effect.

Related Experiment Videos

Area of Science:

Rheumatology
Dermatology
Pharmacology

Background:

Dermatomyositis is a rare autoimmune disease causing muscle and skin inflammation.
Statins are widely prescribed lipid-lowering drugs.
Previous reports linked other statins, like pravastatin, to rare musculocutaneous syndromes.

Observation:

A 71-year-old woman developed dermatomyositis.
The patient had positive Mi-2-Antibodies, a specific marker for dermatomyositis.
Her condition emerged after treatment with simvastatin.

Findings:

This is the first reported case of simvastatin-induced dermatomyositis.
The patient's presentation and antibody profile were consistent with dermatomyositis.
The temporal association suggests simvastatin as a potential trigger.

Implications:

Simvastatin should be considered a potential cause of dermatomyositis.
This finding is significant given the increasing use of statins.
Further research is needed to confirm this association and understand the mechanism.