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Published on: December 7, 2016
Vascular changes after intra-bleb injection of bevacizumab
Michael A Coote1, Jonathan B Ruddle, Queena Qin
1Centre for Eye Research Australia, University of Melbourne, Melbourne, Vic 8002, Australia.
Purpose:
To illustrate changes in bleb vascularity after subconjunctival bevacizumab injection.
Methods:
Longitudinal changes in bleb vascularity were followed over 6 months pre and postbevacizumab injection.
Results:
Bleb vascularity associated with increased scarring activity was observed 10 days postcataract surgery in an eye that had undergone trabeculectomy 3 months previously. A single subconjunctival avastin injection led to a dramatic reduction in bleb vascularity for 6 weeks. With continued steroids, a diffuse, healthy, well functioning bleb with minimal scar tissue was present at 6 months.
Conclusions:
Subconjunctival injection of bevacizumab reduced bleb vascularity and may provide an adjunct to current antifibrosis therapy. Further studies to establish the effect of bevacizumab on postoperative scaring are warranted.
