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Related Concept Videos

Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Doppler Optical Coherence Tomography of Retinal Circulation
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Enhanced Detection of Glaucoma Progression Using Widefield Swept-Source OCT.

Marc G Sarossy1, Maxime Jannaud2, Xavier Hadoux1

  • 1Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia; Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Australia.

Ophthalmology. Glaucoma
|September 24, 2025
PubMed
Summary
This summary is machine-generated.

Widefield OCT scans detect glaucoma progression more effectively than conventional cpRNFLT measurements. This advanced imaging reduces sample size needs for clinical trials, improving glaucoma detection rates.

Keywords:
Ganglion Cell ComplexGlaucomaOCTProgressionWidefield

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Glaucoma diagnosis and progression monitoring rely on structural measurements.
  • Conventional methods like circumpapillary retinal nerve fiber layer thickness (cpRNFLT) have limitations in detecting subtle changes.
  • Widefield swept-source OCT offers a broader view of the retina.

Purpose of the Study:

  • To compare the effectiveness of widefield swept-source OCT scans versus cpRNFLT measurements for detecting glaucoma progression.
  • To assess the potential of widefield OCT in improving glaucoma diagnostic accuracy and trial efficiency.

Main Methods:

  • A longitudinal study involving 156 eyes from 115 glaucoma participants.
  • Acquisition of circumpapillary circle scans (spectral-domain OCT) and widefield 15x15 mm OCT volume scans.
  • Two graders qualitatively assessed widefield OCT scans for ganglion cell complex (GCC) thickness changes over 12 months, masked to time intervals.

Main Results:

  • Widefield OCT identified over twice as many progressing eyes (36.7-38.1%) compared to cpRNFLT (16.8%) at 95% specificity.
  • In eyes with mean deviation (MD) ≥-6 dB, widefield OCT detected ≥3 times more progression (41.1-46.3%) than cpRNFLT (13.7%).
  • Widefield OCT imaging reduced sample size requirements for clinical trials by 69-80%.

Conclusions:

  • Qualitative evaluation of widefield OCT scans demonstrates superior detection rates for structural glaucoma progression compared to cpRNFLT.
  • Widefield OCT represents a more sensitive tool for monitoring glaucoma and enhancing clinical trial design.