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Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

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Related Experiment Video

Updated: Jun 29, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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Published on: May 14, 2016

Cancer therapy: targeting cell cycle regulators.

Martin Johansson1, Jenny Liao Persson

  • 1Department of Laboratory Medicine, Lund University, Malmö University Hospital, 205 02, Malmö, Sweden.

Anti-Cancer Agents in Medicinal Chemistry
|October 16, 2008
PubMed
Summary
This summary is machine-generated.

Novel agents targeting cell cycle pathways offer new hope for cancer treatment. This review explores drugs that interfere with tumor cell mitosis and highlights natural product-derived cyclin-dependent kinase (CDK) inhibitors.

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Related Experiment Videos

Last Updated: Jun 29, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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Published on: May 14, 2016

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11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cyclins and cyclin-dependent kinases (CDKs) regulate DNA synthesis and cell division.
  • Dysregulation of cell cycle control is a hallmark of cancer, often involving elevated cyclins and CDKs.
  • Understanding cell cycle response to chemotherapy is crucial for enhancing treatment efficacy and overcoming resistance.

Purpose of the Study:

  • To review the development of novel therapeutic agents targeting cell cycle pathways in human cancers.
  • To discuss drugs that directly inhibit tumor cell mitosis.
  • To highlight the potential of small molecule CDK inhibitors derived from natural products.

Main Methods:

  • Literature review of recent advancements in cell cycle-targeted cancer therapeutics.
  • Analysis of drug mechanisms interfering with mitotic processes.
  • Exploration of natural product-derived compounds as CDK inhibitors.

Main Results:

  • Elevated cyclins and CDKs are common in various human cancers.
  • Novel agents are being developed to target specific cell cycle pathways.
  • Natural products show promise as sources for small molecule CDK inhibitors.

Conclusions:

  • Targeting cell cycle pathways presents a promising strategy for cancer therapy.
  • Developing drugs that inhibit mitosis and utilize natural product-derived CDK inhibitors can improve treatment outcomes.
  • Further research is needed to overcome drug-induced cytotoxicity and resistance.