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Matrix embedded microspherules containing indomethacin as controlled drug delivery systems
K M Lokamatha Swamy1, B Satyanath, S M Shantakumar
1Department of Pharmaceutics, V.L.College of Pharmacy, Raichur-584 103, Karnataka, India. lkmswamy@rediffmail.com
Current Drug Delivery
|October 16, 2008
Summary
Controlled drug delivery systems were developed using wax/fat microspherules for indomethacin. Paraffin wax demonstrated the most significant drug release retardation, offering prolonged therapeutic effects.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Controlled drug delivery systems aim to optimize therapeutic efficacy and patient compliance.
- Wax and fat matrices offer hydrophobic properties suitable for barrier coatings and taste masking of bitter drugs like indomethacin.
Purpose of the Study:
- To develop and characterize indomethacin-loaded microspherules using various wax/fat matrices for controlled drug release.
- To investigate the influence of different wax/fat compositions on drug release kinetics and mechanisms.
Main Methods:
- Microspherules containing indomethacin were prepared using emulsification-phase separation with cetostearyl alcohol, paraffin wax, and stearic acid.
- Emulgents including methyl cellulose, sodium alginate, and Tween-80 were employed.
- Drug content uniformity, release kinetics, and surface morphology via Scanning Electron Microscope (SEM) were analyzed.
Main Results:
- Uniform drug content was achieved across all microspherule batches.
- Drug release followed first-order kinetics, with paraffin wax exhibiting the greatest retardation.
- Release mechanisms involved anomalous diffusion and Super Case II transport, correlating with microspherule size.
Conclusions:
- Wax/fat microspherules provide an effective platform for controlled indomethacin delivery.
- Paraffin wax is a promising matrix material for achieving prolonged drug release.
- Microspherule size and composition significantly influence drug release profiles and mechanisms.
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