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Coated hydrophilic polystyrene-based packing materials.

Y B Yang1, F E Regnier

  • 1Department of Biochemistry, Purdue University, West Lafayette, IN 47907.

Journal of Chromatography
|May 17, 1991
PubMed
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A novel hydrophilic chromatography base support was developed using coated poly(styrene-divinylbenzene) beads. This advancement offers enhanced stability and derivatization potential for various chromatographic applications.

Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Polymer Chemistry

Background:

  • High-performance liquid chromatography (HPLC) requires robust and versatile stationary phases.
  • Existing supports often lack sufficient hydrophilicity or chemical stability.
  • Developing new base supports is crucial for advancing chromatographic techniques.

Purpose of the Study:

  • To create a highly hydrophilic base support for chromatography.
  • To ensure chemical stability and broad solvent compatibility.
  • To enable diverse derivatization for various chromatographic modes.

Main Methods:

  • Microparticulate, macroporous poly(styrene-divinylbenzene) beads were used as the base material.
  • A coating containing cross-linking functionalities was applied.

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  • A catalyzed cross-linking reaction formed stable chemical bonds and hydroxyl groups.

    • Main Results:

    • A very hydrophilic base support was successfully synthesized.
    • The coatings exhibited excellent chemical stability and solvent compatibility.
    • The support demonstrated low irreversible adsorption and good rigidity.
    • Derivatives were successfully prepared and tested in different chromatography modes.

    Conclusions:

    • The developed coated poly(styrene-divinylbenzene) support is a promising material for HPLC.
    • Its hydrophilicity, stability, and derivatization potential make it suitable for various chromatographic applications.
    • This novel support advances the field of stationary phase development.