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Severe hyponatraemia in malaria.

S H Khoo1, E G Wilkins

  • 1Lister Unit for Infectious Disease, Northwick Park Hospital, Harrow, Middlesex, U.K.

The Journal of Infection
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

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Severe hyponatraemia and hypoglycaemia occurred in a patient with falciparum malaria. Large volumes of intravenous dextrose for quinine may worsen fluid overload and hyponatraemia.

Area of Science:

  • Infectious Diseases
  • Endocrinology
  • Critical Care Medicine

Background:

  • Falciparum malaria is a severe infectious disease with potential for multiple organ complications.
  • Hyponatraemia and hypoglycaemia are known, though less common, complications of severe malaria.
  • Management of severe malaria often involves intravenous medications, requiring careful consideration of diluents and fluid balance.

Observation:

  • A patient with complicated falciparum malaria presented with severe hyponatraemia (low sodium levels) and hypoglycaemia (low blood sugar).
  • The patient received large volumes of intravenous dextrose solution as a diluent for quinine therapy.
  • This administration led to significant fluid overload.

Findings:

  • The use of large volumes of intravenous dextrose as a diluent for quinine therapy was associated with fluid overload.

Related Experiment Videos

  • Fluid overload in this context may exacerbate pre-existing or developing hyponatraemia.
  • This case highlights a potential iatrogenic contribution to electrolyte disturbances in severe malaria management.

    • Implications:

    • Clinicians should exercise caution when administering large fluid volumes, particularly dextrose solutions, to patients with severe malaria.
    • Careful monitoring of fluid balance and serum electrolytes is crucial during quinine therapy in malaria patients.
    • Alternative diluents or administration strategies may be considered to mitigate the risk of fluid overload and hyponatraemia in severe malaria.