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Updated: Aug 17, 2026

Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension
Published on: December 5, 2020
Ultrasound properties of liver with and without particulate contrast agents
T A Tuthill1, R B Baggs, M R Violante
1Department of Electrical Engineering, University of Rochester, NY 14627.
Abstract:
Basic acoustic parameters are examined in rabbit liver with and without a solid contrast agent used for tumor detection. In normal liver, backscatter, attenuation, and sound speed are found to decrease with increasing water content. The addition of micron-sized particles made from iodipamide ethyl ester (IDE) can increase backscatter and attenuation depending on size and concentration. A discrepancy of the increased backscatter from theoretical predictions based on random scatterers is attributed to the particle's biodistribution in the liver.
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