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Aluminium absorption in infancy.

F Chedid1, A Fudge, J Teubner

  • 1Department of Paediatrics, Flinders Medical Centre, Bedford Park, South Australia.

Journal of Paediatrics and Child Health
|June 1, 1991
PubMed
Summary
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Infants absorb aluminum from common antacid medications, leading to increased plasma and urinary aluminum levels. This absorption raises significant concerns about potential aluminum toxicity in vulnerable infants.

Area of Science:

  • Neonatal medicine
  • Pediatric toxicology
  • Clinical chemistry

Background:

  • Aluminum-containing medications and contaminated infant formulas are frequently used.
  • Infants may be particularly susceptible to the adverse effects of aluminum due to immature organ systems.

Purpose of the Study:

  • To investigate aluminum absorption in infants following the ingestion of aluminum-containing antacids.
  • To assess the impact of antacid therapy on plasma and urinary aluminum levels in neonates.

Main Methods:

  • Seven infants with a mean gestational age of 36 weeks received antacid therapy (400-800 mumol aluminum) with feeds for two days.
  • Plasma and urinary aluminum levels were measured before and after the antacid treatment period.
  • Urinary aluminum was normalized to creatinine levels for analysis.

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Main Results:

  • Plasma aluminum levels significantly increased from 0.64 +/- 0.33 mumol/L to 3.48 +/- 2.86 mumol/L (P = 0.029) after antacid therapy.
  • A notable increase in the urinary aluminum to creatinine ratio was observed.
  • These findings indicate significant aluminum absorption in the infant participants.

Conclusions:

  • Infants demonstrate absorption of aluminum when administered antacids.
  • The observed increase in plasma aluminum levels reached potentially toxic concentrations.
  • These results highlight the risk of aluminum toxicity in infants using aluminum-based antacids.