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Tropical myositis: ultrastructural studies.

J F Taylor, D Fluck, D Fluck

    Journal of Clinical Pathology
    |December 1, 1976
    PubMed
    Summary
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    Electron microscopy revealed potential viral particles within muscle cells of tropical myositis patients. These findings suggest a viral etiology for this inflammatory muscle disease.

    Area of Science:

    • Tropical Medicine
    • Pathology
    • Virology

    Background:

    • Tropical myositis is an inflammatory muscle condition prevalent in tropical regions.
    • The exact cause of tropical myositis remains poorly understood, necessitating further investigation into potential etiologies.

    Purpose of the Study:

    • To investigate the ultrastructural pathology of muscle tissue in patients diagnosed with tropical myositis.
    • To identify potential causative agents, such as viruses, associated with the observed muscle degeneration.

    Main Methods:

    • Muscle biopsy specimens were collected from nine patients presenting with non-suppurating lesions of tropical myositis.
    • Electron microscopy was employed to examine the ultrastructural changes within the muscle fibers and surrounding cells.
    • Control tissue sections were used for comparative analysis.

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    Main Results:

    • Patchy myocytolysis and loss of muscle band structure were observed in all examined specimens.
    • Degenerative changes were noted in perimysial cells.
    • Intracellular vesicles, approximately 80 nm in diameter, containing 10 nm granules, were identified in two patients.
    • These vesicles exhibited budding from cell membranes and morphological similarities to virus particles.
    • Focal necrosis was associated with these vesicles, which were absent in control tissues.

    Conclusions:

    • The presence of virus-like particles and associated focal necrosis suggests a potential viral etiology for tropical myositis.
    • Further research, including viral isolation and characterization, is warranted to confirm the role of these particles in the disease process.