Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new glucose clamp algorithm: clinical validation.

A Campostano1, F Altomonte, D Bessarione

  • 11a Divisone di Medicina, Ospedale S. Martino, Genova, Italy.

The International Journal of Artificial Organs
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New Insights Into the Genetic Variability of <i>Fasciola Hepatica</i> (Trematoda) in Algeria and Relationships with Other Geographic Regions Revealed By Mitochondrial DNA.

Helminthologia·2022
Same author

Morphological and genetic variability of the cryptic <i>Gyrodactylus sphinx</i> and <i>Gyrodactylus gerasevi</i> n. sp. (Platyhelminthes: Monogenea) from the Mediterranean Sea and Black Sea: two new members of the cross-ocean distributed <i>Gyrodactylus orecchiae</i> species group.

Journal of helminthology·2022
Same author

Species diversity and molecular insights into phlebotomine sand flies in Sardinia (Italy)-an endemic region for leishmaniasis.

Parasitology research·2019
Same author

Nanoscale organization in the fluorinated room temperature ionic liquid: Tetraethyl ammonium (trifluoromethanesulfonyl)(nonafluorobutylsulfonyl)imide.

The Journal of chemical physics·2018
Same author

Direct experimental observation of mesoscopic fluorous domains in fluorinated room temperature ionic liquids.

Physical chemistry chemical physics : PCCP·2017
Same author

23Na NMR relaxation studies of the Na-DNA/drug interaction.

Chemphyschem : a European journal of chemical physics and physical chemistry·2013
Same journal

Therapeutic plasma exchange added to CRRT combined with hemoperfusion in wasp sting-associated AKI: A multicenter retrospective cohort study.

The International journal of artificial organs·2026
Same journal

Development of an early prediction model for ICU-acquired weakness in sepsis using PNI and SII.

The International journal of artificial organs·2026
Same journal

Foot care behaviors and perceived exercise benefits and barriers in diabetic hemodialysis patients.

The International journal of artificial organs·2026
Same journal

First clinical experience with citrate-anticoagulated CVVHD-based low-flow ECCO<sub>2</sub>R in severe hypercapnic respiratory failure.

The International journal of artificial organs·2026
Same journal

Carboxyhemoglobin levels for the detection of hemolysis in patients supported by left ventricular assist devices: A case series.

The International journal of artificial organs·2026
Same journal

Evaluation of arteriovenous fistulas of obtuse anastomosis in reducing thrombosis using computational fluid dynamics.

The International journal of artificial organs·2026
See all related articles

A novel computer-assisted glucose clamp technique using a minimal model algorithm was clinically validated. This automated method significantly reduces priming time and improves glycemic control for insulin sensitivity studies.

Area of Science:

  • Endocrinology
  • Medical Technology
  • Clinical Research

Background:

  • Insulin sensitivity is crucial for metabolic health.
  • Traditional glucose clamp techniques face challenges with priming phases.
  • Accurate in vivo insulin sensitivity assessment is vital for diabetes research.

Purpose of the Study:

  • To validate a new computer-assisted glucose clamp technique for in vivo insulin sensitivity studies.
  • To assess the efficacy of a minimal model algorithm in an artificial pancreas system.
  • To overcome limitations of the priming phase in glucose clamp procedures.

Main Methods:

  • Clinical validation of an automated glucose clamp technique using the "Betalike R" artificial pancreas.
  • Application of a minimal model algorithm for real-time glucose control.

Related Experiment Videos

  • Performance of euglycemic and hyperglycemic hyperinsulinemic clamps in 18 patients.

    • Main Results:

    • The mean priming time to reach steady-state glycemia was reduced to 20 minutes.
    • The automated system minimized glycemic overshoot during the priming phase.
    • Accidental variations in steady-state glycemia were reduced to a minimum, ensuring safety and stability.

    Conclusions:

    • The new automatic glucose clamp technique is safe, stable, and efficient for clinical use.
    • This automated method significantly improves the speed and accuracy of insulin sensitivity assessments.
    • The minimal model algorithm effectively manages the priming phase, enhancing study reliability.