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A computer program for the estimation of kinetic parameters of membrane currents based on the Gauss-Newton method
R Grave de Peralta1, J L Hernández, M Castellanos
1National Center for Scientific Research, Neuroscience Center, Havana, Cuba.
International Journal of Bio-Medical Computing
|May 1, 1991
Abstract:
A computer program based on the Gauss-Newton method was developed for the Hodgkin-Huxley estimation of kinetic parameters of membrane currents recorded in voltage-clamp experiments. Fast potassium current of land snail neurons was estimated, and found to be in agreement with literature reports.