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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

The effect of polysaccharides on the reaction between erythrocytes and viruses, with particular reference to mumps

H S GINSBERG, W F GOEBEL, F L HORSFALL

    The Journal of Experimental Medicine
    |May 1, 1948
    PubMed

    Insights

    Certain polysaccharides inhibit mumps virus multiplication but may not affect hemagglutination or viral adsorption. This suggests complex interactions between polysaccharides, viruses, and host cells, impacting antiviral strategies.

    Area of Science:

    • Virology
    • Biochemistry

    Background:

    • Polysaccharides are known to exhibit antiviral properties.
    • The precise mechanisms of polysaccharide-mediated viral inhibition are not fully understood.

    Purpose of the Study:

    • To investigate the relationship between polysaccharide inhibition of mumps virus multiplication in vivo and their effects on viral hemagglutination and adsorption in vitro.
    • To determine if polysaccharides that inhibit viral replication also prevent viral attachment to host cells.

    Main Methods:

    • Assessing the inhibitory effects of various polysaccharides on mumps virus replication in the allantoic sac of embryonated eggs.
    • Evaluating the ability of these polysaccharides to inhibit hemagglutination by mumps virus.
    • Testing the capacity of these polysaccharides to prevent the adsorption of mumps virus to erythrocytes and allantoic membrane cells.

    Main Results:

    • Polysaccharides inhibiting mumps virus multiplication did not consistently inhibit hemagglutination or viral adsorption to erythrocytes.
    • Evidence suggests these active polysaccharides do not block mumps virus adsorption to living allantoic membrane cells.
    • A similar lack of correlation between in vitro and in vivo inhibitory activity was observed for influenza A, influenza B, Newcastle disease virus, and PVM.

    Conclusions:

    • The antiviral activity of polysaccharides against mumps virus is complex and not solely dependent on blocking viral adsorption or hemagglutination.
    • Polysaccharide inhibition of viral replication may occur through mechanisms other than direct interference with initial viral attachment.
    • Findings highlight the need for further research into the specific molecular interactions governing polysaccharide-virus-host cell dynamics for developing effective antiviral therapies.
    Keywords:
    PAROTITISSACCHARIDES

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