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Updated: Aug 10, 2026
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Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
Published on: August 30, 2020
Sickle cell disease and aneurysmal subarachnoid hemorrhage
H H Batjer1, T E Adamson, G W Bowman
1Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas 75235-8855.
Surgical Neurology
|August 1, 1991
Summary
Sickle cell disease patients rarely experience aneurysmal subarachnoid hemorrhage. This case highlights multiple aneurysms and posterior circulation involvement, common in such rare occurrences.
Area of Science:
- Neurology
- Vascular Medicine
- Hematology
Background:
- Neurological complications are frequent in sickle cell disease (SCD).
- Aneurysmal subarachnoid hemorrhage (aSAH) is an uncommon complication in SCD patients.
- The pathophysiology linking SCD to arterial abnormalities requires further elucidation.
Observation:
- A case of a young male SCD patient presenting with subarachnoid hemorrhage is described.
- The patient was diagnosed with two mid-basilar aneurysms, one of which had ruptured.
- This presentation aligns with existing literature on SCD-associated aneurysms.
Findings:
- Nearly 50% of documented SCD-associated aneurysm cases involve multiple aneurysms.
- Posterior circulation aneurysms are frequently observed in this patient population.
- The arterial destruction in SCD may predispose individuals to aneurysm formation.
Implications:
- This case underscores the importance of considering aneurysmal subarachnoid hemorrhage in SCD patients with neurological symptoms.
- The findings suggest a potential link between SCD pathophysiology and the development of multiple, particularly posterior, circulation aneurysms.
- Further research into the vascular mechanisms in SCD is warranted to improve patient outcomes and diagnostic strategies.
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