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Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Inflammation01:38

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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Inflammatory Response01:28

Inflammatory Response

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Acute Inflammation III: Local and Systemic Effects

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Updated: Jun 28, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Inflammation and prostate cancer.

Sonya Vasto1, Giuseppe Carruba, Giuseppina Candore

  • 1Department of Pathobiology and Biomedical Methodologies, Immunohaemathology and Transfusion Medicine Unit, University Hospital, University of Palermo, Palermo, Italy. s.vasto@unipa.it

Future Oncology (London, England)
|October 17, 2008
PubMed
Summary
This summary is machine-generated.

Inflammation and sex hormones may drive prostate cancer development. Early inflammatory events, potentially triggered by hormone imbalances like elevated estrogens and testosterone, could be a prerequisite for prostate cancer onset.

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Published on: March 6, 2018

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Last Updated: Jun 28, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Area of Science:

  • Oncology
  • Urology
  • Endocrinology

Background:

  • Prostate cancer is a significant health concern globally.
  • Inflammation is increasingly recognized for its role in carcinogenesis.
  • Chronic inflammation and prostate inflammation are linked to prostate cancer development.

Purpose of the Study:

  • To explore the potential role of inflammation and sex hormones in prostate cancer initiation.
  • To investigate the link between hormone-induced inflammation and prostate cancer risk.

Main Methods:

  • Literature review on inflammation, sex hormones, and prostate cancer.
  • Analysis of existing research on carcinogenesis and prostate cancer etiology.

Main Results:

  • Inflammation can promote carcinogenesis through cellular damage and altered microenvironments.
  • Elevated endogenous gonadal steroids, particularly estrogens with testosterone, induce prostate-specific inflammation.
  • Hormone-stimulated inflammatory events may precede prostate cancer development.

Conclusions:

  • Sex hormones may initiate prostate cancer by triggering inflammatory responses.
  • Early inflammatory events influenced by hormonal factors could be crucial for prostate cancer onset.
  • Further research is warranted to elucidate the precise mechanisms linking hormones, inflammation, and prostate cancer.