Physiopathology of the aging heart

Filippo Cademartiri1, Ludovico La Grutta, Pim J de Feyter

  • 1Department of Radiology and Cardiology, Erasmus Medical Center, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands. filippocademartiri@hotmail.com

Insights

Coronary heart disease is a major health concern for older adults. This review highlights aging

Area of Science:

  • Cardiology
  • Geriatrics
  • Medical Imaging

Background:

  • Coronary heart disease (CHD) is the primary cause of illness and death in the elderly population.
  • Aging involves physiological changes that increase the risk and impact of heart disease.
  • High prevalence of both clinical and subclinical heart disease necessitates preventive strategies.

Purpose of the Study:

  • To review the prevalence and impact of heart disease in older adults.
  • To discuss increasing risk factors and physiological changes associated with aging.
  • To focus on advanced noninvasive imaging techniques for cardiac assessment.

Main Methods:

  • Review of existing literature on aging, heart disease, and risk factors.
  • Focus on recently developed noninvasive cardiac imaging modalities.
  • Specific mention of cardiac multislice computed tomography (CT) and cardiac magnetic resonance (MR) imaging.

Main Results:

  • Aging significantly increases the risk and prevalence of coronary heart disease in the elderly.
  • Noninvasive imaging techniques offer new avenues for early detection and management.
  • Cardiac multislice CT and MR imaging are highlighted as key advancements.

Conclusions:

  • Despite advances, coronary heart disease remains a critical issue for older adults.
  • Understanding aging-related physiological changes is crucial for prevention.
  • Advanced noninvasive imaging like cardiac CT and MR holds promise for improved cardiac care in the elderly.

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...