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Related Experiment Video

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A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

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Aging and the respiratory system.

Lorenzo Bonomo¹, Anna Rita Larici, Fabio Maggi

¹Department of Bioimaging and Radiological Sciences, Catholic University of the Sacred Heart, Policlinico Agostino Gemelli, L.go F. Vito 8, 00168 Rome, Italy. lbonomo@rm.unicatt.it

Radiologic Clinics of North America

|October 17, 2008

Summary

Aging chests present unique findings between normal and abnormal. Recognizing these age-related physiological changes is crucial for accurate diagnosis and timely treatment in elderly patients.

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Last Updated: Jun 28, 2026

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

Area of Science:

Geriatric Medicine
Radiology
Cardiology
Pulmonology

Background:

Aging leads to physiological chest changes, often mistaken for pathology.
Elderly individuals have higher incidences of illness and multiple comorbidities.
Differentiating normal aging from disease is critical for appropriate medical care.

Purpose of the Study:

To elucidate the diagnostic challenges in elderly chest imaging.
To highlight the importance of understanding age-related physiological modifications.
To introduce the concepts of "cardiac lung" and "pulmonary heart" in geriatric patients.

Main Methods:

Review of imaging findings in elderly patients.
Analysis of physiological changes associated with aging in the chest.
Correlation of clinical and radiological signs with cardiac and pulmonary conditions.

Main Results:

Identified a spectrum of chest findings in the elderly that are neither normal nor clearly pathological.
Emphasized the need to distinguish age-related changes from true pathologies.
Highlighted the utility of diagnostic imaging in clarifying complex clinical presentations.

Conclusions:

Accurate interpretation of chest imaging in the elderly requires recognizing normal aging processes.
Understanding "cardiac lung" and "pulmonary heart" models aids in early diagnosis and treatment.
Image diagnostics is essential for managing the frequent multipathologies in older adults.