Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Semaglutide improves markers of cardiovascular risk in people with HIV.

AIDS (London, England)·2026
Same author

Durable protection against SIV challenge by adeno-associated virus delivery of Env-specific antibodies.

bioRxiv : the preprint server for biology·2026
Same author

Primary liver cancer in Georgia: Seven years' experience following the launch of the Hepatitis C Elimination Program, 2015-2022.

PloS one·2026
Same author

Pilot study of epigenetic aging and treatment response to semaglutide in the SLIM LIVER study.

npj aging·2026
Same author

Development and genomic characterization of a diverse HIV-1 variant reference panel for nucleic acid-based testing.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2026
Same author

Longitudinal evaluation of HIV-1 LAg incidence assay and proficiency panel stability for external quality assurance.

Microbiology spectrum·2026

Related Experiment Video

Updated: Jun 28, 2026

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
08:11

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Published on: September 1, 2015

CD4 immunophenotyping in HIV infection.

David Barnett1, Brooke Walker, Alan Landay

  • 1UK NEQAS for Leukocyte Immunophenotyping, Rutledge Mews, 3 Southbourne Road, Sheffield, S10 2QN UK. d.barnett@sheffield.ac.uk

Nature Reviews. Microbiology
|October 25, 2008
PubMed
Summary
This summary is machine-generated.

Accurate CD4 cell enumeration is vital for managing HIV/AIDS. This overview discusses historical CD4 testing advancements and current challenges in developing cost-effective, reliable diagnostic methods for HIV-infected individuals.

More Related Videos

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
09:26

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function

Published on: October 15, 2013

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Related Experiment Videos

Last Updated: Jun 28, 2026

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.
08:11

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Published on: September 1, 2015

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
09:26

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function

Published on: October 15, 2013

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Area of Science:

  • Clinical Immunology
  • Diagnostic Immunology
  • Infectious Diseases

Background:

  • The identification of immune cell subsets, such as CD4 cells, marked a significant advancement in immunology.
  • This breakthrough coincided with the emergence of the HIV/AIDS pandemic, highlighting the clinical importance of CD4 cell counts.
  • The evolution of HIV/AIDS and treatment strategies necessitates precise CD4 cell enumeration for patient management.

Purpose of the Study:

  • To provide a historical perspective on the development of CD4 enumeration technologies relevant to HIV infection.
  • To summarize the ongoing technological challenges in CD4 cell counting.
  • To emphasize the need for affordable, reliable, and accurate CD4 enumeration methods for individuals living with HIV.

Main Methods:

  • Review of historical developments in CD4 enumeration technologies.
  • Analysis of current technological limitations and challenges.
  • Synthesis of information related to HIV infection and CD4 cell counting.

Main Results:

  • Significant advancements in CD4 cell identification have occurred alongside the HIV/AIDS pandemic.
  • Current methods face challenges in meeting the demand for affordable, reliable, and accurate CD4 enumeration.
  • The historical trajectory shows a continuous need for improved diagnostic tools.

Conclusions:

  • Affordable, reliable, and accurate CD4 enumeration methods are critical for managing HIV infection.
  • Overcoming current technological challenges is essential to meet the needs of the global HIV-infected population.
  • Continued innovation in CD4 testing is crucial for effective HIV/AIDS care and treatment strategies.