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Related Experiment Video

Updated: Jun 28, 2026

Intracellular Refolding Assay

Intracellular Refolding Assay

Published on: January 24, 2012

Heat shock proteins and exercise: a primer.

Earl G Noble¹, Kevin J Milne, C W James Melling

¹School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, ON N6A3K7, Canada. enoble@uwo.ca

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme

|October 17, 2008

Summary

Heat shock proteins (HSPs) are vital prosurvival molecules. Exercise significantly increases HSPs in muscles, offering protection against various stressors and influencing inflammation and ion channels.

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Area of Science:

Cellular Biology
Exercise Physiology

Background:

Heat shock proteins (HSPs) are crucial prosurvival molecules.
Overexpression of HSPs confers protection against diverse cellular stressors.
Exercise is a potent stimulus for increasing HSPs in tissues like heart and skeletal muscle.

Purpose of the Study:

To review major HSP families and their functions.
To explore the control of HSP expression.
To examine the influence of exercise on HSPs, particularly in muscle.

Main Methods:

Literature review of HSPs and exercise.
Introduction to related symposium topics: exercise paradigms, inflammation, and ion channel effects.

Main Results:

Exercise robustly increases HSPs in cardiac and skeletal muscle.
HSPs play roles in cellular protection and adaptation to stress.
Related reviews cover exercise effects on muscle HSPs, inflammation, and ion channels.

Conclusions:

HSPs are key players in cellular adaptation to stress, with exercise being a significant modulator.
Understanding HSPs offers potential therapeutic avenues for stress-related conditions.
This review series explores diverse roles of HSPs in physiology and disease.