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Updated: Jun 28, 2026
05:19
Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
[Gastroesophageal reflux disease and malignancy]
Zoé Richert1, Michel Robaszkiewicz
1Service d'hépato-gastroentérologie, hôpital de La Cavale-Blanche, CHU de Brest, Université de Bretagne occidentale, 29609 Brest Cedex, France. zoe.richert@chu-brest.fr
La Revue Du Praticien
|October 18, 2008
Summary
Gastroesophageal reflux disease (GERD) can lead to Barrett's esophagus, a precancerous condition. Early detection via endoscopy in at-risk men may enable timely treatment of esophageal adenocarcinoma.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Context:
- Severe gastroesophageal reflux disease (GERD) is a significant risk factor for Barrett's esophagus.
- Barrett's esophagus involves the replacement of squamous epithelium with columnar epithelium in the distal esophagus.
- This condition is a precancerous state with a risk of malignant transformation.
Purpose:
- To outline the risk factors and diagnostic considerations for Barrett's esophagus and esophageal adenocarcinoma.
- To discuss the incidence and potential benefits of surveillance for Barrett's mucosa.
- To highlight endoscopic treatment options for early-stage disease.
Summary:
- Barrett's esophagus, a consequence of severe GERD, carries a risk of developing into adenocarcinoma.
- Risk factors include GERD, obesity, male gender, and age; endoscopy is recommended for symptomatic men over 50.
- Surveillance may detect high-grade dysplasia or early adenocarcinoma, allowing for curative treatment, including endoscopic mucosal resection.
Impact:
- Facilitates early detection of esophageal adenocarcinoma in high-risk populations.
- Informs clinical practice regarding the screening and surveillance of Barrett's esophagus.
- Promotes awareness of endoscopic treatment modalities for precancerous esophageal conditions.
Related Concept Videos
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This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
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