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Related Concept Videos

Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Enhanced Elimination of Poison01:26

Enhanced Elimination of Poison

Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:

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Related Experiment Video

Updated: Jun 28, 2026

A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis
07:33

A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis

Published on: March 15, 2016

[Corrosive substance ingestions management].

Ljiljana Jovancević1, Dragan Dankuc

  • 1Klinicki centar Vojvodine, Klinika za bolesti uva, grla i nosa, 21000 Novi Sad, Hajduk Veljkova 1-7. ljjovan@eunet.yu

Medicinski Pregled
|October 18, 2008
PubMed
Summary

Corrosive substance ingestion requires immediate stabilization and dilution. Oesophagoscopy is key for diagnosing esophageal lesions, with specific contraindications for treatment.

Area of Science:

  • Gastroenterology
  • Toxicology
  • Emergency Medicine

Context:

  • Acute poisonings from corrosive substances constitute a significant portion of all poisonings.
  • Corrosive ingestion leads to severe gastrointestinal tract lesions, primarily affecting the esophagus (alkali) or stomach (acid).

Purpose:

  • To outline a comprehensive treatment protocol for acute corrosive substance ingestion.
  • To emphasize timely stabilization, dilution, diagnosis, and appropriate therapeutic interventions.

Summary:

  • Initial management involves stabilizing vital signs and diluting the ingested substance with water or milk within 60 minutes.
  • Oesophagoscopy is the preferred diagnostic tool for assessing esophageal damage.
  • Key therapeutic principles include avoiding induced vomiting, diarrhea, neutralization, and gastric lavage; charcoal is ineffective.

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Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube

Published on: April 28, 2020

Manual Restraint and Common Compound Administration Routes in Mice and Rats
14:10

Manual Restraint and Common Compound Administration Routes in Mice and Rats

Published on: September 26, 2012

Related Experiment Videos

Last Updated: Jun 28, 2026

A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis
07:33

A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis

Published on: March 15, 2016

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube
06:12

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube

Published on: April 28, 2020

Manual Restraint and Common Compound Administration Routes in Mice and Rats
14:10

Manual Restraint and Common Compound Administration Routes in Mice and Rats

Published on: September 26, 2012

Impact:

  • The presented protocol, in use since 2000, has demonstrated excellent patient outcomes.
  • Highlights the importance of identifying the ingested substance, withholding oral intake, and monitoring fluid/electrolyte balance and complications.