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Related Experiment Video

Updated: Jun 28, 2026

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

Published on: August 12, 2016

Soft drinks and weight gain: how strong is the link?

Emily Wolff¹, Michael L Dansinger

¹Boston University School of Medicine, Boston, Massachusetts, USA. ewolff@mcd.org

Medscape Journal of Medicine

|October 18, 2008

Summary

While observational studies link sugar-sweetened soft drinks to weight gain, more clinical trials are needed to confirm this causal relationship. Reducing consumption may slow weight gain in adolescents.

Area of Science:

Nutrition Science
Public Health
Clinical Research

Background:

Soft drink consumption has tripled in the U.S. over recent decades.
This increase parallels rising obesity prevalence.
Evidence linking sugar-sweetened beverages to weight gain requires evaluation.

Purpose of the Study:

To evaluate the scientific evidence for a causal link between sugar-sweetened soft drink consumption and weight gain.
To synthesize findings from observational studies and clinical trials.

Main Methods:

Conducted a MEDLINE search (1966-2006) for articles on "soft drinks" and "weight."
Included cross-sectional, prospective cohort, and clinical trial data in humans.
Reviewed references from retrieved articles and a systematic review.

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A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration

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Published on: February 6, 2014

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Last Updated: Jun 28, 2026

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Published on: February 6, 2014

Main Results:

Six of 15 cross-sectional and 6 of 10 prospective cohort studies showed significant associations between soft drink intake and increased body weight.
Two clinical trials in adolescents suggested reducing intake slowed weight gain.
Three small adult trials indicated sugar-sweetened soft drinks caused weight gain, but were short-term and small-scale.

Conclusions:

Observational data support a link between sugar-sweetened soft drinks and weight gain.
A lack of robust clinical trial data leaves the causal link debated.
Larger, longer intervention trials are needed to clarify effects on weight and cardiovascular risk factors.