Laboratory evaluation of the COBAS MIRA S random access analyser

The random access analyser COBAS MIRA S (Roche Diagnostics) was evaluated for two months. The instrument is a computer-controlled discrete analyser which can be run in a combination profile and single test mode. This instrument has special features, including an automatic cuvette segment changer, a reagent rack cooling system, an external keyboard and monitor, as well as a bar-code facility for the entry of test parameters, worklists and sample identification numbers. Study of within-run and between-run precision gave values of % CV 0.54-3.37 and 0.61-3.65, respectively, for a variety of assays. Linearity testing to the upper limit of each test was also studied and were found to cover the necessary pathological range. Within the two-month period, no major problems were encountered. The instrument required minimum operator attention during operation. Correlation studies with the Hitachi 705 using six clinical chemistry tests (glucose, cholesterol, triglyceride, ALP, AST, ALT) gave correlation coefficients ranging from 0.95-0.99 and slopes of 0.91-1.17.