Investigation of the steady state measurement process

Area of Science:

• Analytical Chemistry
• Measurement Science

Background:

• The concept of steady state is crucial in analytical chemical measurement models.
• A strictly mathematical steady state is often not achievable in real-world measurements.

Purpose of the Study:

• To introduce and define 'practically steady state' (PSS) for analytical measurements.
• To develop a method for detecting the steady state of a measurement process using analytical information.
• To determine simultaneously present systematic and random errors.

Main Methods:

• Defined 'practically steady state' (PSS) requiring errors within limits and expected values within a range.
• Utilized peak area ratio as analytical information to detect measurement process steady state.
• Employed internal standard measurements for control and error determination.

Main Results:

• The proposed method effectively determines simultaneously present systematic and random errors.
• Internal standard control provides useful data but requires additional information.
• The method allows prediction of the end of the steady state measurement process.

Conclusions:

• The PSS definition offers a practical approach to steady state in analytical chemistry.
• The developed method aids in identifying and quantifying measurement errors.
• Internal standards can signal disturbances and predict process interruptions.