Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Introduction to Developmental Psychology01:27

Introduction to Developmental Psychology

Developmental psychology explores the changes and continuities in human abilities throughout life, encompassing physical, cognitive, linguistic, and social dimensions. Human development is not restricted to growth, but includes aspects of decline, particularly in physical abilities as individuals age. Developmental psychologists seek to understand how people change as they age and how their mental and social skills evolve.Developmental MilestonesA key concept in developmental psychology is...
The Nativist Approach01:21

The Nativist Approach

The nativist approach to infant cognitive development proposes that infants are born with inherent knowledge structures that allow them to interpret the world almost immediately. This perspective contrasts with earlier developmental theories, such as those proposed by Jean Piaget, which emphasized a more gradual acquisition of cognitive abilities through interaction with the environment. One key concept in this approach is object permanence — the understanding that objects continue to exist...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gentle and efficient engineering of primary human NK cells by photoporation with polydopamine nanosensitizers.

Journal of controlled release : official journal of the Controlled Release Society·2025
Same author

Case Report: Atypical acute compartment syndrome of the forearm in a child following minor trauma with consecutive osteomyelitis.

Frontiers in surgery·2024
Same author

PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis.

Leukemia·2020
Same author

An accelerated, clinical-grade protocol to generate high yields of type 1-polarizing messenger RNA-loaded dendritic cells for cancer vaccination.

Cytotherapy·2018
Same author

[74-year-old man with a complex acromio-clavicular disjunction].

Revue medicale de Bruxelles·2018
Same author

Radiation Sensitivity of Human CD34(+) Cells Versus Peripheral Blood T Lymphocytes of Newborns and Adults: DNA Repair and Mutagenic Effects.

Radiation research·2016
Same journal

The interaction between inflammation and estrogen in adenomyosis : from molecular mechanisms to therapeutic strategies.

Seminars in immunopathology·2026
Same journal

The complex of gut microbial metabolites and sex hormones in Alzheimer's disease.

Seminars in immunopathology·2026
Same journal

Endometrial pathophysiology and pregnancy: from mechanism to intervention.

Seminars in immunopathology·2026
Same journal

Advances in understanding the dual roles of testicular immune responses: From immune privilege to inflammation.

Seminars in immunopathology·2026
Same journal

Climate change-associated heat extremes and immune dysregulation: emerging links with autoimmunity, allergy, and infectious diseases.

Seminars in immunopathology·2026
Same journal

The cancer-microbiome axis: Mechanisms and emerging therapeutic strategies.

Seminars in immunopathology·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

Preparation and Applications of Organotypic Thymic Slice Cultures
10:10

Preparation and Applications of Organotypic Thymic Slice Cultures

Published on: August 6, 2016

Human intrathymic development: a selective approach.

J Plum1, M De Smedt, G Leclercq

  • 1Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University, De Pintelaan 185, 4 Blok A, 9000, Ghent, Belgium. jean.plum@ugent.be

Seminars in Immunopathology
|October 18, 2008
PubMed
Summary
This summary is machine-generated.

Human T lymphocytes can develop from progenitor cells in various settings. Mouse thymus or stromal cells expressing Delta-like1 can support human T cell differentiation, influencing the T cell repertoire.

More Related Videos

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
08:21

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

Related Experiment Videos

Last Updated: Jun 28, 2026

Preparation and Applications of Organotypic Thymic Slice Cultures
10:10

Preparation and Applications of Organotypic Thymic Slice Cultures

Published on: August 6, 2016

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy
08:21

Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy

Published on: October 2, 2018

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

Area of Science:

  • Immunology
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Human T lymphocytes are crucial for adaptive immunity.
  • Generating functional human T cells from progenitor cells is essential for research and therapeutic applications.
  • Understanding the microenvironments that support T cell differentiation is key to controlling immune responses.

Purpose of the Study:

  • To review and discuss the different environments that support human T cell generation from CD34 progenitor cells.
  • To analyze how these diverse environments influence the developing human T cell repertoire.
  • To explore the role of xenogeneic thymus and Notch signaling in T cell differentiation.

Main Methods:

  • In vivo studies involving transplantation of human thymic tissue and fetal liver into immunodeficient mice.
  • In vitro studies using hybrid human-mouse fetal thymus organ cultures.
  • Co-culture systems with murine stromal cells expressing Delta-like1 ligand.

Main Results:

  • Human T cells can be generated from CD34 progenitor cells in immunodeficient mice, with or without co-transplanted human thymus.
  • Xenogeneic mouse thymus tissue effectively supports human T cell differentiation.
  • Murine stromal cells expressing Delta-like1 ligand also support human T cell generation.

Conclusions:

  • Multiple microenvironments, including xenogeneic mouse thymus and Notch-ligand expressing stromal cells, can support human T cell development.
  • These findings highlight the plasticity of T cell differentiation pathways.
  • Further research is needed to fully elucidate how these environments shape the human T cell repertoire.