Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A cloud-based miniscope for neurosurveillance of brain health and disease in freely behaving animals.

Nature methods·2026
Same author

A mechanistic computational model of the HIF signaling pathway in endothelial cells.

iScience·2026
Same author

From complexity to clarity: aging bone marrow niche in bone and blood regeneration and malignancy.

Bone research·2026
Same author

Protocol: A multi-factorial, multi-centre study, for biomarker identification in healthy controls for comparison to babies with moderate-severe NESHIE.

PloS one·2026
Same author

Sensorineural regulation of skull healing implicates FGF1 signaling in non-healing bone.

bioRxiv : the preprint server for biology·2025
Same author

An epigenetic perspective on neonatal encephalopathy with suspected hypoxic ischaemic encephalopathy.

Clinical epigenetics·2025
Same journal

Endothelial Notch1 drives multicellular remodelling during hyaloid vessel regression.

Angiogenesis·2026
Same journal

Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer.

Angiogenesis·2026
Same journal

miR-150 controls developmental angiogenesis via ribosome biogenesis-dependent regulation of Notch signaling.

Angiogenesis·2026
Same journal

MCC links Wnt/PCP signaling to endothelial polarity and vascular remodeling.

Angiogenesis·2026
Same journal

Endothelial AGO1 deficiency reduces breast cancer burden in mice.

Angiogenesis·2026
Same journal

Soluble CD146 reflects altered endothelial and metabolic homeostasis in peripheral artery disease.

Angiogenesis·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Circulating and imaging markers for angiogenesis.

Arvind P Pathak1, Warren E Hochfeld, Simon L Goodman

  • 1JHU ICMIC Program, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. pathak@mri.jhu.edu

Angiogenesis
|October 18, 2008
PubMed
Summary
This summary is machine-generated.

Anti-angiogenesis therapy shows promise for inhibiting tumor growth, validated by recent successes in colon cancer. New circulating and imaging markers are needed to dynamically monitor tumor angiogenesis in vivo.

More Related Videos

A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics
12:09

A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

Published on: June 16, 2013

In vivo Imaging of Tumor Angiogenesis using Fluorescence Confocal Videomicroscopy
05:08

In vivo Imaging of Tumor Angiogenesis using Fluorescence Confocal Videomicroscopy

Published on: September 11, 2013

Related Experiment Videos

Last Updated: Jun 28, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics
12:09

A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

Published on: June 16, 2013

In vivo Imaging of Tumor Angiogenesis using Fluorescence Confocal Videomicroscopy
05:08

In vivo Imaging of Tumor Angiogenesis using Fluorescence Confocal Videomicroscopy

Published on: September 11, 2013

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Anti-angiogenesis is a validated strategy for inhibiting tumor growth, supported by preclinical and clinical data.
  • Vascular Endothelial Growth Factor (VEGF) neutralizing antibodies have shown success in metastatic colon carcinoma patients.
  • The clinical success of anti-angiogenesis necessitates reliable surrogate markers.

Purpose of the Study:

  • To review the need for reliable markers of angiogenesis.
  • To discuss the limitations of current markers like microvessel density.
  • To explore the development of circulating and imaging markers for in vivo monitoring of angiogenesis.

Main Methods:

  • Review of preclinical and clinical data on anti-angiogenesis.
  • Analysis of the utility of microvessel density as a surrogate marker.
  • Discussion on the requirements for novel circulating and imaging markers.

Main Results:

  • Microvessel density is a static "snap-shot" and insufficient for dynamic assessment.
  • There is an acute need for non-invasive, in vivo markers of angiogenesis.
  • Circulating and imaging markers are required for repeated monitoring in diverse tumor types.

Conclusions:

  • Anti-angiogenesis is a clinically relevant cancer treatment strategy.
  • Current markers for angiogenesis lack dynamic and in vivo assessment capabilities.
  • Development of novel circulating and imaging markers is crucial for effective monitoring and management of angiogenesis in cancer.