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Toxicity and activity of purified trichosanthin
P Ferrari1, M A Trabaud, M Rommain
1Laboratories Cassenne, Centre de Recherches Immunologiques Roussel-Uclaf, Cergy Pontoise, France.
AIDS (London, England)
|July 1, 1991
Abstract:
Trichosanthin was purified from fresh Chinese root tubers of Trichosanthes kirilowii and evaluated for anti-HIV activity. Trichosanthin inhibited syncytium formation between infected H9 cells and uninfected Sup-T1 cells from 0.5 to 4 micrograms/ml. Trichosanthin also inhibited HIV replication in H9 and CEM-SS cells at 1 microgram/ml, but was toxic for MT-4 cells (HTLV-I-positive), at doses greater than 0.25 microgram/ml. This new purification procedure confirms the anti-HIV activity of trichosanthin on some cell lines in different biological assays.