Related Experiment Video
Updated: Jun 28, 2026

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels
Published on: September 8, 2016
Loopy MSC: a simple way to improve multiplicative scatter correction
Willem Windig1, Jeremy Shaver, Rasmus Bro
1Eigenvector Research, Inc., 3905 West Eaglerock Drive, Wenatchee, Washington 98801, USA. windig@eigenvector.com
Abstract:
Multiplicative scatter correction (MSC) is a widely used normalization technique. It aims to correct spectra in such a way that they are as close as possible to a reference spectrum, generally the mean of the data set, by changing the scale and the offset of the spectra. When there are other differences in the spectra than just a scale and an offset, the mean spectrum changes after MSC. As a result, another MSC, with the new mean spectrum as the reference, will result in an additional correction. This paper studies the effect of multiple applications of MSC.
Related Concept Videos
NMR Spectrometers: Resolution and Error Correction
Distance Corrections
Calibration Curves: Linear Least Squares
For data that follow a straight line, the standard method for fitting is the linear...
Propagation of Uncertainty from Systematic Error
Propagation of Uncertainty from Random Error
Calibration Curves: Correlation Coefficient
