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Updated: Jun 28, 2026
10:49
Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
Reproducibility of delayed-type reactions to betalactams
M Rodriguez-Alvarez1, S Santos-Magadan, B Rodriguez-Jimenez
1Allergy Department. Hospital Clínico San Carlos. Madrid. Spain.
Allergologia Et Immunopathologia
|October 22, 2008
Summary
Delayed reactions to betalactam antibiotics are common, but drug challenges show most patients tolerate the medication. A conclusive diagnosis requires a simple blind oral challenge for accurate allergy assessment.
Area of Science:
- Clinical Immunology
- Pharmacology
- Allergy and Immunology
Background:
- Delayed hypersensitivity reactions to betalactam antibiotics are frequently reported.
- These reactions are a common cause for medical consultations and extensive research.
Purpose of the Study:
- To determine if delayed betalactam antibiotic reactions are reproducible via drug challenge.
- To characterize individuals experiencing these delayed reactions.
Main Methods:
- Study included 23 patients with a history of delayed (>72h) betalactam reactions.
- Methods involved skin prick tests (SPT), intradermal tests (IT), patch tests, and simple blind placebo-controlled drug challenges (SBPCDC).
Main Results:
- SPT and patch tests were negative in all participants.
- Only one patient had positive IT tests; allergic reactions were reproduced in only two patients.
- A significant 76% of patients tolerated the suspected betalactam antibiotic.
Conclusions:
- Simple blind oral challenge followed by home treatment is essential for diagnosing delayed betalactam antibiotic allergies.
- This diagnostic approach is crucial for accurate patient management.
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