Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Widefield OCT angiography" [Progress in Retinal and Eye Research. 107 (2025) 101378].

Progress in retinal and eye research·2025
Same author

Widefield OCT angiography.

Progress in retinal and eye research·2025
Same author

A system for producing controlled elevation of intraocular pressure in awake Brown Norway rats.

Experimental eye research·2025
Same author

112° field of view high-resolution swept-source OCT angiography for rat retinas.

Optics letters·2024
Same author

Controlled Elevation of Intraocular Pressure (CEI) Glaucoma Model in Rats.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

Controlled elevation of intraocular pressure in anesthetized mice.

Experimental eye research·2024
Same journal

Preface.

Progress in brain research·2025
Same journal

Mindfulness and meditation: Promoting emotional and cognitive health.

Progress in brain research·2025
Same journal

Cognitive stimulation enhancing memory and mental function.

Progress in brain research·2025
Same journal

The science behind non-pharmacological interventions.

Progress in brain research·2025
Same journal

Technology-assisted interventions for neuropsychiatric disorders.

Progress in brain research·2025
Same journal

Ethical consideration in non-pharmacological treatments for neuropsychiatric disorders.

Progress in brain research·2025
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Rat models for glaucoma research.

John C Morrison1, Elaine Johnson, William O Cepurna

  • 1Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA. morrisoj@ohsu.edu

Progress in Brain Research
|October 22, 2008
PubMed
Summary
This summary is machine-generated.

Rats are a valuable model for studying optic nerve injury in primary open-angle glaucoma (POAG). Research shows a strong correlation between elevated intraocular pressure (IOP) and nerve damage in these models.

More Related Videos

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Related Experiment Videos

Last Updated: Jun 28, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice
07:00

A Model of Glaucoma Induced by Circumlimbal Suture in Rats and Mice

Published on: October 5, 2018

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Glaucoma Research

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Understanding the mechanisms of optic nerve damage is crucial for developing effective treatments.
  • Rats are emerging as a relevant model system for studying POAG due to conserved cellular structures.

Purpose of the Study:

  • To evaluate the utility of rat models in elucidating the mechanisms of optic nerve injury relevant to human POAG.
  • To investigate the relationship between elevated intraocular pressure (IOP) and optic nerve damage in rat models.
  • To assess the suitability of specific IOP elevation methods for mimicking human glaucoma pathology.

Main Methods:

  • Utilizing rat models with experimentally elevated intraocular pressure (IOP).
  • Employing methods like hypertonic saline injection and laser treatment to increase resistance to aqueous humor outflow.
  • Implementing specialized instrumentation for precise measurement of IOP exposure and fluctuations.
  • Correlating IOP levels with the extent of optic nerve damage observed.

Main Results:

  • Rat optic nerve head (ONH) shares ultrastructural similarities with human ONH, suggesting relevance of observed cellular processes.
  • Specific IOP elevation methods induce regional injury patterns potentially mirroring human glaucoma.
  • High susceptibility of the rodent ONH to elevated IOP necessitates precise pressure monitoring.
  • A strong correlation was established between IOP exposure and the degree of nerve damage.

Conclusions:

  • Rat models offer a valuable platform for studying the cellular mechanisms underlying pressure-induced optic nerve damage in POAG.
  • Continued research using these models is expected to enhance our understanding of POAG pathogenesis.
  • The findings support the use of these models for preclinical investigations into glaucoma therapies.