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In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

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Published on: June 8, 2017

Cerebral malaria and the hemolysis/methemoglobin/heme hypothesis: shedding new light on an old disease

Ana Pamplona1, Thomas Hanscheid, Sabrina Epiphanio

  • 1Unidade de Malária, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649-028 Lisboa, Portugal. anapamplona@fm.ul.pt

The International Journal of Biochemistry & Cell Biology
|October 22, 2008
PubMed

Malaria causes more than 1 million deaths every year with cerebral malaria (CM) being a major cause of death in Sub-Saharan African children. The nature of the malaria-associated pathogenesis is complex and multi-factorial. A unified hypothesis involving sequestration of infected red blood cells, systemic host inflammatory response and hemostasis dysfunction has been proposed to explain the genesis of CM. In this review, we discuss the role of hemolysis, methemoglobin and free heme in CM, brought to light by our recent studies in mice as well as by other studies in humans.

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