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Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
06:18

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

First report of chikungunya from the Maldives

Abdul Azeez Yoosuf1, Ibrahim Shiham, Ahmed Jamsheed Mohamed

  • 1Ministry of Health, Malé 20379, Republic of Maldives.

Transactions of the Royal Society of Tropical Medicine and Hygiene
|October 22, 2008
PubMed

Insights

Chikungunya virus outbreak confirmed in the Maldives in 2006. This mosquito-borne illness caused widespread fever and joint pain, affecting over 11,000 people across 61% of islands.

Area of Science:

  • Medical Entomology
  • Infectious Diseases
  • Epidemiology

Background:

  • An outbreak of fever, arthralgia, and myalgia occurred in the Maldives starting December 2006.
  • Clinical symptoms and regional epidemics suggested chikungunya virus as the cause.

Purpose of the Study:

  • To investigate and confirm the presence of chikungunya virus during the 2006-2007 outbreak in the Maldives.

Main Methods:

  • Blood samples were collected from 67 patients.
  • Chikungunya virus infection was detected using IgM antibody testing and PCR.
  • Dengue virus co-infection was assessed via enzyme immunosorbent assay.

Main Results:

  • 21% of patients were IgM-positive and 96% were PCR-positive for chikungunya.
  • 6% tested positive for dengue, with 4% showing dual infection.
  • The epidemic affected 11,879 individuals across 61% of inhabited islands by April 2007.

Conclusions:

  • Chikungunya fever was confirmed for the first time in the Maldives.
  • The outbreak had a significant attack rate, impacting a large proportion of the island nation.

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