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Associated Chromosome Trap for Identifying Long-range DNA Interactions

Associated Chromosome Trap for Identifying Long-range DNA Interactions

Published on: April 23, 2011

Long-range chromosomal interactions and gene regulation.

Adriana Miele¹, Job Dekker

¹Program in Gene Function and Expression, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605-0103, USA.

Molecular Biosystems

|October 22, 2008

Summary

New insights reveal that gene regulatory elements physically interact with distant genes and other chromosomes to control gene expression. A network approach is proposed to understand these complex long-range gene regulation interactions.

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Area of Science:

Genetics
Molecular Biology
Genomics

Background:

Gene expression is regulated by elements that can be distant on the same chromosome or on different chromosomes.
Recent research has uncovered significant new information regarding long-range gene regulation.

Purpose of the Study:

To provide an overview of newly discovered long-range chromosomal interactions.
To propose a network-based approach for understanding gene-element relationships in gene regulation.

Main Methods:

Review and description of well-characterized cases of long-range interactions.
Speculation on mechanisms facilitating encounters between distant regulatory elements and genes.

Main Results:

Gene regulatory elements physically interact with target genes and loci on other chromosomes.
These interactions modulate transcription, influencing gene activation and repression.

Conclusions:

Long-range chromosomal interactions form complex genome-wide networks that control gene expression.
Genome-wide network analysis offers a promising approach to decipher the logic of long-range gene regulation.