Related Experiment Video

Updated: Jun 28, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

Publication biases and phase II trials investigating anticancer targeted therapies

Nicolas Penel1, Antoine Adenis

  • 1Medical Oncology, Centre Oscar Lambret, 3 rue Combemale, 59020, Lille, France.

Investigational New Drugs
|October 22, 2008
PubMed

Insights

Journal impact factor for phase II trials (P2T) investigating molecular targeted therapies (MTT) is most affected by the trial

Area of Science:

  • Oncology
  • Clinical Pharmacology
  • Biomedical Research

Background:

  • Molecular targeted therapies (MTT) represent a significant advancement in cancer treatment.
  • Phase II trials (P2T) are crucial for evaluating the efficacy and safety of novel MTT.
  • Understanding factors influencing the publication impact of P2T reports is important for disseminating research findings.

Purpose of the Study:

  • To identify key parameters influencing the impact factor (IF) of journals publishing P2T reports on MTT.
  • To analyze the relationship between trial outcomes and journal IF in the field of MTT.

Main Methods:

  • A systematic review of 74 P2T reports investigating MTT (imatinib, sorafenib, sunitinib, dasatinib) published between January 2002 and June 2008.
  • Analysis of journal IF as a function of various trial-related parameters, including trial outcome.

Main Results:

  • The final outcome of the P2T was the most significant parameter affecting journal IF.
  • Median IF for journals publishing negative P2T results was significantly lower (2.71) compared to those publishing positive results (6.14) (p = 0.004).

Conclusions:

  • The success or failure of a molecular targeted therapy in a phase II trial substantially impacts the visibility and influence of its published report.
  • Positive trial results are associated with higher journal impact factors, potentially leading to wider dissemination of promising MTT research.

More Related Videos

Assessing Specificity of Anticancer Drugs In Vitro09:39

Assessing Specificity of Anticancer Drugs In Vitro

Published on: March 23, 2016

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...