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Soft tissue sarcoma of the pleural cavity
Cancer
|October 1, 1991
Summary
Chronic pleural inflammation may lead to soft tissue sarcoma (STS) in the pleura. This study reviewed 17 cases, finding malignant fibrous histiocytoma most common and a poor survival rate.
Area of Science:
- Thoracic Oncology
- Pathology
- Epidemiology
Background:
- Soft tissue sarcoma (STS) in the pleural cavity is rare.
- Chronic pleural inflammation, including pleuritis, pyothorax, and tuberculosis, may precede sarcoma development.
Purpose of the Study:
- To summarize clinical and pathological findings of pleural STS.
- To investigate potential risk factors, such as chronic pleural inflammation, for pleural STS development.
Main Methods:
- Retrospective review of 17 Japanese cases of pleural STS.
- Analysis of clinical history, pathological findings, treatment, and survival data.
Main Results:
- Malignant fibrous histiocytoma (11 cases) and angiosarcoma (4 cases) were the most common types.
- Eight patients (47%) had a history of chronic pleural inflammation (mean duration 28.8 years).
- The 1-year survival rate was 38.5%, with a mean survival of 14.2 months post-treatment.
Conclusions:
- Long-standing pleural inflammation is a potential risk factor for pleural STS.
- Pleural STS has a poor prognosis, emphasizing the need for early detection and treatment.