Fibroblast growth factor-induced increased survival of cholinergic mesopontine neurons in culture
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E Garcia-Rill1, D L Davies, R D Skinner
1Department of Anatomy, University of Arkansas for Medical Sciences, Little Rock 72205.
Brain Research. Developmental Brain Research
|June 21, 1991
Abstract:
Basic fibroblast growth factor (bFGF) was found to increase the survival of immunocytochemically-identified cholinergic mesopontine neurons in dissociated cell cultures of embryonic rat midbrain. In contrast, cultures exposed to, (a) bFGF and an antibody to bFGF, (b) antibody to bFGF alone, or (c) untreated, contained approximately half the number of cholinergic neurons compared to bFGF-treated cultures.