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Change in EEG Activity is Associated with a Decrease in Tinnitus Awareness after rTMS.

G Carter¹, R B Govindan², G Brown³

¹Department of Anatomy and Physiology, National Park College, USA.

Frontiers in Neurology and Neuroscience Research

|July 15, 2021

Summary

This summary is machine-generated.

Repetitive transcranial magnetic stimulation (rTMS) can reduce tinnitus awareness, particularly with 1Hz frequency. This improvement is linked to increased beta coherence in EEG, suggesting a potential biomarker for treatment response.

Keywords:

10Hz 1Hz EEG TCD coherence placebo rTMS repetitive transcranial magnetic stimulation spectral power thalamocortical dysrhythmia tinnitus

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Area of Science:

Neuroscience
Neuromodulation
Audiology

Background:

Tinnitus is often associated with thalamocortical dysrhythmia (TCD).
Repetitive transcranial magnetic stimulation (rTMS) is being investigated as a potential treatment for tinnitus.
Understanding the neural mechanisms underlying rTMS effects is crucial for optimizing treatment.

Purpose of the Study:

To investigate the effects of 1Hz and 10Hz rTMS on tinnitus loudness, annoyance, and awareness.
To test the thalamocortical dysrhythmia (TCD) model of tinnitus by analyzing EEG changes.
To correlate EEG alterations with changes in tinnitus perception following rTMS.

Main Methods:

A double-blind, placebo-controlled, within-subjects study with 19 participants.
rTMS (1Hz and 10Hz) applied over the temporal cortex for four days.
Assessment of tinnitus ratings and 64-channel resting-state EEGs at baseline and post-treatment.

Main Results:

No immediate effect of rTMS observed within a single session.
1Hz rTMS significantly decreased tinnitus awareness after accounting for regression to the mean.
Increased beta coherence in EEG correlated significantly with reduced tinnitus awareness, particularly in responders.

Conclusions:

rTMS-induced changes in beta coherence may serve as a biomarker for tinnitus treatment response.
Increased beta coherence suggests a 'top-down' modulation promoting tinnitus habituation.
Non-responders to rTMS did not exhibit significant changes in EEG patterns.