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Updated: Jun 28, 2026

Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay
Published on: January 12, 2022
ADAM function in embryogenesis
Dominique Alfandari1, Catherine McCusker, Hélène Cousin
1Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Paige lab. Rm. 203, 161 Holdsworth Way, Amherst, MA 01003, United States. alfandar@vasci.umass.edu
Abstract:
Cleavage of proteins inserted into the plasma membrane (shedding) is an essential process controlling many biological functions including cell signaling, cell adhesion and migration as well as proliferation and differentiation. ADAM surface metalloproteases have been shown to play an essential role in these processes. Gene inactivation during embryonic development have provided evidence of the central role of ADAM proteins in nematodes, flies, frogs, birds and mammals. The relative contribution of four subfamilies of ADAM proteins to developmental processes is the focus of this review.
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